Steer clear of the use of promethazine HCl and codeine phosphate oral Remedy in adolescents 12 to 18 years of age who have other risk factors that will maximize their sensitivity to your respiratory depressant results of codeine.

Since recurrences of NMS have already been described with phenothiazines, prevent use of promethazine HCl and codeine phosphate oral Alternative in sufferers with a historical past regular with NMS.

Codeine is a Program II drug, as outlined during the Managed Substances Act, meaning it has both a substantial prospective for abuse and habit and is just meant for prescribed professional medical makes use of including relieving delicate soreness or minimizing coughing.

Reproductive toxicity studies have not been executed with promethazine HCl and codeine phosphate oral Resolution; nonetheless, scientific studies can be obtained with personal Energetic elements (see Information).

Respiratory issues (respiratory melancholy) that may result in Dying and opioid withdrawal can happen if you start using or end getting other medicines although having Promethazine Hydrochloride and Codeine Phosphate Oral Solution, such as:

The next adverse reactions have been determined through scientific scientific tests, during the literature, or in the course of put up-acceptance usage of codeine and/or promethazine.

Codeine Within an embryofetal advancement analyze in pregnant rats dosed throughout the period of organogenesis, codeine greater resorptions and lowered fetal weights at a dose around 25 instances the MRHD (on a mg/m2 foundation with a maternal oral dose of 120 mg/kg/day); however, these effects transpired inside the presence of maternal toxicity.

The causal function of opioids while in the scientific syndrome of hypogonadism is unidentified as the numerous medical, Bodily, Way of living, and psychological stressors that will influence gonadal hormone concentrations haven't been sufficiently controlled for in scientific studies performed to date [see Adverse Reactions (6)].

The everyday cocaine that is purchased on the street is often a white or a little off-white powder that may be bitter when tasted and it will cause numbness from the mouth and tongue. Higher-potency cocaine is pearly white in physical appearance. Because of its iridescent shine, it is termed fish scale cocaine.

The opioid antagonists, naloxone and nalmefene, are particular antidotes for respiratory melancholy ensuing from opioid overdose. For clinically significant respiratory or circulatory melancholy secondary to codeine overdose, administer an opioid antagonist. An antagonist really should not be administered inside the absence of clinically considerable respiratory despair. As the duration of opioid reversal is predicted being under the period of action of codeine in promethazine HCl and codeine phosphate oral Resolution, very carefully observe the individual until spontaneous respiration is reliably reestablished.

Postmarketing scenarios website of respiratory melancholy, together with fatalities happen to be described with usage of promethazine in pediatric patients.

Be certain you know how to acquire this product and what other drugs you ought to steer clear of taking with it. See also Drug Interactions portion. Get professional medical support at once if any of these very significant Unintended effects come about: sluggish/shallow respiratory, uncommon lightheadedness, significant drowsiness/dizziness, difficulty waking up.

Within the mid 1800s, cocaine was to start with isolated from coca leaves and by 1880, it had been currently being widely employed for medicinal uses. The drug ongoing to get level of popularity, but with it came some dangerous Unintended effects and consequences. In 1922, cocaine was officially banned, making it illegal to implement during the U.S. 

Request your pharmacist to give you a measuring gadget to assist you to measure the right volume of Promethazine with Codeine Oral Option. Never utilize a domestic teaspoon to evaluate your medication. It's possible you'll accidently take an excessive amount of.